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Has anyone experienced newly acquired or an increase in antibiotic allergies since acquiring the infection? I was diagnosed four years ago with a new infection. While the outbreaks have slowed down, I do continue to have outbreaks. I take Valtrex sporadically as it causes me to become macrocytic. Within the last two years I have reacted allergically to two antibiotics, different types, that I was never previously allergic to, both times with a rash. I was able to dig up research that in the presence of Epstein-Barr or mono, also in the herpes family, people have been known to react allergically to antibiotics. My own strain is HSV2, and the infection is active. I wonder if anyone else has experienced this?