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Needhelp19

Western Blot Results vs IGG ELISA Confusion

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I took the IGG test for HSV1 and 2 2 weeks after I believed I was exposed to HSV1. The results came back negative for HSV2 but positive for HSV1 with an index value of 3.87. Not wanting to believe the results I took the Western Blot 6 weeks later. The results for HSV1  and 2 came back negative. 
 

My doctor insisted that the infection had to be old since it showed up so quickly on the IGG but if it was already an established infection why didn’t it show up on the Western Blot? It’s been 6 months now and I have not experienced an type of outbreak. Should I assume that I don’t have herpes or should I take the Western Blot again since I didn’t wait 3-6 months to take it the first time?

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Hi @Needhelp19! IgG is notorious for giving both false positives and negatives, so it’s not a definitive test by any means. (Which is unfortunate since that’s the most common test out there! Go figure.) 🤦‍♂️ 

And yes, you’re on it — in order to get an accurate Western blot even, you would need to wait for antibodies to build up to detectable levels, which is that 12 to 16 week timeframe. 


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I'd say your result with IgG was a false pos. If it was an established infection the western blot would of picked it up. Or you may have the protein that trips  the  igG testing. 

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On 1/4/2020 at 2:56 PM, Tone12 said:

I'd say your result with IgG was a false pos. If it was an established infection the western blot would of picked it up. Or you may have the protein that trips  the  igG testing. 

What is this protein?  Does it trip the testing in to a false negative or false positive?

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On 1/8/2020 at 8:10 PM, TreeHugger44 said:

What is this protein?  Does it trip the testing in to a false negative or false positive?

According to Terri Warren some people carry this protein to trip the test into a low number false positive. Not negative. 

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